PI3K inhibitor
Catalog No. P27-900C
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| P27-900C-05 | 5 mg | $55 | |
| P27-900C-25 | 25 mg | $225 | |
| P27-900C-BULK | BULK | Contact Us |
Overview:
Highly selective inhibitor of phosphatidylinositol 3-kinase (IC50 = 0.31, 0.73, 1.06 and 6.60 uM for PI 3-Kbeta, PI 3-Kalpha, PI 3-Kdelta and PI 3-Kgamma respectively) (1). Inhibits autophagy in rat hepatocytes (IC50 = 10 uM) (2). An extremely useful tool for determining the role of PI 3-K in cellular signaling (3).
References:
1. CJ Vlahos et al. J. Biol. Chem. 1994 269:5241
2. EF Blomaart et al. Eur. J. Biochem. 1997 243:240
3. S Chasserot-Golaz et al. J. Neurochem. 1998 70:2347
CAS Registry Number:
154447-36-6
Molecular Formula:
C19H17NO3
Appearance:
White to pale-yellow powder
Melting Point:
182-183oC
Molecular Weight:
307.2
Purity:
>98% (TLC); NMR (Conforms)
Solubilization:
May be dissolved in DMSO (100 mg/ml)
Aliases:
2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
Storage and Stability:
Storage, Stability and Shipping
Molecular Structure:
|
AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, Invasion/Metastasis, Lipid Kinases, Metabolic Disorder, Neurobiology, NfkB Pathway, WNT Signaling
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Fax: 1-604-232-4601
Yalcin Abdullah et al., Nuclear Targeting of 6-Phosphofructo-2-kinase (PFKFB3) Increases Proliferation via Cyclin-dependent Kinases* Journal of Biological Chemistry November 2012 10.1074/jbc.M109.016816 
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