cFMS kinase inhibitor
Catalog No. C74-901
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| C74-901-05 | 5 mg | $90 | |
| C74-901-25 | 25 mg | $345 | |
| C74-901-BULK | BULK | Contact Us |
Overview:
Potent and selective inhibitor of cFMS receptor kinase. Completely inhibits cFMS in vitro at 60 nM with no activity against 26 other kinases (1). Completely inhibits CSF-1 induced growth of mouse M-NFS-60 myeloid cells and human monocytes (at 1 uM) (1). Completely inhibits bone degradation in human osteoclasts, rat calvaria and fetal long bone (1). Inhibits LPS-induced TNF production in mice. Abrogates infiltration of macrophages into synovial joints of arthritic mice (2). Active in vivo.
References:
1. JG Conway et al Proc. Natl. Acad. Sci. USA 2005 102:16078
2. RT Paniagua et al. Arthritis Res. Ther. 2010 12:R32
CAS Registry Number:
870483-87-7
Molecular Formula:
C20H22N4O3
Appearance:
Off-white solid
Melting Point:
209-210oC
Molecular Weight:
366.4
Purity:
≥98% (TLC); NMR (Conforms)
Solubilization:
May be dissolved in DMSO (40 mg/ml)
Aliases:
5-(3-methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine
Storage and Stability:
Store desiccated as supplied at ambient temperature for up to 2 years. Store solutions at -20oC for up to 3 months.
Molecular Structure:
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There are no related publications available for this product.
Cancer, Cardiovascular Disease, Cytoplasmic Tyrosine Kinases, Metabolic Disorder
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