LRRK2 inhibitor
Catalog No. L10-901
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| L10-901-05 | 5 mg | $90 | |
| L10-901-25 | 25 mg | $360 | |
| L10-901-BULK | BULK | Contact Us |
Overview:
Novel, potent and selective inhibitor of the leucine-rich repeat kinase-2 (LRRK2), IC50 = 1.28 nM. Also inhibits G2019S mutant LRRK2, IC50 = 1.85 nM (1). Attenuates the neuronal damage elicited by the action of LRRK2 G2019S mutant in primary human neurons (EC50 = 1 nM) (1). The G2019S mutant is a common mutation found in familial Parkinson’s disease patients (2). Cell permeable.
References:
1. LH Wang et al. J. Immunol. 1999 162:3897
2. N Meydan et al. Nature 1996 379:645
CAS Registry Number:
1199911-27-9
Molecular Formula:
C22H25ClN6O4S ∙ HCl
Appearance:
Off-white solid
Melting Point:
N/A
Molecular Weight:
541.5
Purity:
≥98% (TLC); NMR (Conforms)
Solubilization:
May be dissolved in DMSO (50 mg/ml)
Aliases:
N-[-[[5-Chloro-2-[[2-methoxy-4-(4-morpholinyl) phenyl] amino]-4-pyrimidinyl] amino] phenyl] methanesulfonamide hydrochloride
Storage and Stability:
Store desiccated as supplied at ambient temperature for up to 1 year. Store solutions at -20oC for up to 1 month.
Molecular Structure:
|
There are no related publications available for this product.
Neurobiology
STAY CONNECTED
Fax: 1-604-232-4601
Toll Free: 1-866-954-6273
info@signalchem.com