PKG inhibitor
Catalog No. P78-900
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| P78-900-100 | 100 ug | $140 | |
| P78-900-500 | 500 ug | $540 | |
| P78-900-BULK | BULK | Contact Us |
Overview:
Selective protein kinase G inhibitor (Ki = 0.23, 4 and > 10 uM for inhibition of PKG, PKC and PKA respectively). Inhibits SNP-stimulated PKG activity (IC50 of 60 nM) in dispersed smooth muscle cells and has little effect on PKA activity at concentrations of up to 10 uM. Cell permeable.
References:
1. H Kase et al. Biochem. Biophys. Res. Commun. 1987 142:436
2. Gadbois et al . Proc.Natl.Acad.Sci.1996 89:8626.
3. Murthy and Makhlouf. Am.J.Physiol. 1995 268:C171.
4. Smolenski et al. Naunyn Schmiedebergs Arch.Pharmacol. 1998 358:134
CAS Registry Number:
126643-37-6
Molecular Formula:
C29H25N3O5
Appearance:
White to off-white powder
Melting Point:
N/A
Molecular Weight:
495.5
Purity:
>98% (TLC); NMR (Conforms)
Solubilization:
May be dissolved in DMSO (25 mg/ml); or DMF (20 mg/ml)
Aliases:
2,3,9,10,11,12-hexahydro-10R-methoxy-2,9-dimethyl-1-oxo-9S,12R-epoxy-1H-diindolo[1,2,3-fg:3’,2’,1’-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, methyl ester
Storage and Stability:
Storage, Stability and Shipping
Molecular Structure:
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There are no related publications available for this product.
Apoptosis/Autophagy, Cardiovascular Disease, ERK/MAPK Pathway, Neurobiology, NfkB Pathway, PKA/PKC Pathway, Ser/Thr Kinases
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