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CK1 gamma 3, Active

Full length recombinant human CK1 gamma 3 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. C68-10CG


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Catalog No. Pack Size Price (USD)
C68-10CG-05 5 ug $226
C68-10CG-10 10 ug $325
C68-10CG-BULK BULK Contact Us  


Overview:

CK1gamma3 is a member of the CK1 family of serine/threonine protein kinases which play an important role in diverse cell processes, including DNA replication and repair. CK1gamma3 is a ubiquitously expressed protein kinase found in the nuclei, cytoplasm and membrane fractions of eukaryotic cells (1). CK1gamma3 preferentially phosphorylates acidic substrates using ATP as a phosphate donor. The kinase domain of CKI isoforms have been shown to associate with protein kinase C-potentiated inhibitor protein of 17kDa, called CPI-17 (2). CPI-17 specifically inhibits myosin light chain phosphatase and this effect is potentiated when it is phosphorylated on Thr-38 by protein kinases such as the CK1 isoforms.


Gene Aliases:

CSNK1G3


Genbank Number:


References:


1. Kusuda, J. et al: Cloning and chromosome mapping of the human casein kinase I gamma-3 gene (CSNK1G3). Cytogenet. Cell Genet. 83: 101-103, 1998.

2. Zemlickova, E. et al: Association of CPI-17 with protein kinase C and casein kinase I. Biochem Biophys Res Commun. 2004 Mar 26;316(1):39-47.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~73 kDa



Product Datasheets



RESEARCH AREAS

Cancer, Inflammation, Neurobiology, NfkB Pathway, Ser/Thr Kinases, WNT Signaling


RELATED PRODUCTS


  CK1 gamma 2, Active, C68-10BG

  CK1 epsilon, Active, C66-10G

  Casein Protein, C03-54N

  Casein, Dephosphorylated, C03-54BN


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