KAT4 is a DNA-binding protein complex required for RNA polymerase II-mediated transcription of many, if not all, protein-encoding genes in eukaryotic cells. KAT4 plays a key role in the initiation process, since it binds to the TATA element to form a complex that nucleates the assembly of the other components into a preinitiation complex and that may be stable through multiple rounds of transcription. KAT4 may be targeted to specific chromatin-bound promoters and may play a key role in chromatin recognition (1). KAT4 also serves to link the control of transcription to the cell cycle (2).
BA2R; CCG1; CCGS; DYT3; DYT3/TAF1; TAF1; N-TAF1; NSCL2; OF; P250; TAF2A
1. Jacobson, R. H. et.al: Structure and function of a human TAFII250 double bromodomain module. Science 288: 1422-1425, 2000.
2. Starr, D. B. et.al: TFIID binds in the minor groove of the TATA box. Cell 67: 1231-1240, 1991.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
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Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, Metabolic Disorder, Neurobiology, NfkB Pathway, PKA/PKC Pathway