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CAMK2 delta, Active

Full-length recombinant human CAMK2delta was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. C13-10G


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Catalog No. Pack Size Price (USD)
C13-10G-05 5 ug $226
C13-10G-10 10 ug $325
C13-10G-BULK BULK Contact Us  


Overview:

CAMK2D is a serine/threonine protein kinase that is a member of the type II multifunctional Ca2+/calmodulin-dependent protein kinase family. CAMK2D is abundantly present in human cardiac and skeletal muscle and its levels are increased in the heart of patients suffering from cardiomyopathy (1). In cardiomyocytes, stimulation of beta-1-adrenergic receptor leads to induction of apoptosis, an effect that is mediated by activation of CAMK2D in a PKA-independent manner. In addition, expression studies have revealed the downregulation of CAMK2D in human tumor cells.


Gene Aliases:

CAMKD, MGC44911


Genbank Number:


References:


1. Hoch, B. Et al: Identification and expression of delta-isoforms of the multifunctional Ca(2+)/calmodulin-dependent protein kinase in failing and nonfailing human myocardium. Circ. Res. 84: 713-721, 1999.

2. Zhu, W.-Z. Et al: Linkage of beta-1-adrenergic stimulation to apoptotic heart cell death through protein kinase A-independent activation of Ca(2+)/calmodulin kinase II. J. Clin. Invest. 111: 617-625, 2003.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~77 kDa



Product Datasheets



 A Thorne Curtis et al., Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α Nature Chemical Biology November 2010 10.1038/nchembio.453

 Caroccia Alessia et al., N-(Phenoxyalkyl)amides as MT(1) and MT(2) ligands: antioxidant properties and inhibition of Ca(2+)/CaM-dependent kinase II. Bioorganic & Medicinal Chemistry February 2013 10.1016/j.bmc.2012.12.017

 Cipolletta E et al., Calmodulin-Dependent Kinase II Mediates Vascular Smooth Muscle Cell Proliferation and Is Potentiated by Extracellular Signal Regulated Kinase Endocrinology June 2010 10.1210/en.2009-1248

 A. Witczak Carol et al., CaMKII regulates contraction- but not insulin-induced glucose uptake in mouse skeletal muscle. American Journal of Physiology - Endocrinology and Metabolism June 2010 10.1152/ajpendo.00659.2009

 Illario Maddalena et al., Calcium-calmodulin-dependent kinase II (CaMKII) mediates insulin-stimulated proliferation and glucose uptake Cellular signalling January 2007 10.1016/j.cellsig.2009.01.022

 Douglass Jacqueline et al., Identifying Protein Kinase Target Preferences Using Mass Spectrometry American Journal of Physiology - Cell Physiology June 2012 10.1152/ajpcell.00166.2012

 C Bruno et al., The chemosensitizing agent lubeluzole binds calmodulin and inhibits Ca(2+)/calmodulin-dependent kinase II. European Journal of Medicinal Chemistry June 2016 10.1016/j.ejmech.2016.03.045

 Monterrey Gomez et al., Characterization of a selective CaMKII peptide inhibitor European Journal of Medicinal Chemistry April 2013 10.1016/j.ejmech.2012.12.053

 KY Lee et al., Phosphorylation of Serine 235 of the Hepatitis C Virus Non-Structural Protein NS5A by Multiple Kinases. PLoS One November 2016 10.1371/journal.pone.0166763


RESEARCH AREAS

Cardiovascular Disease, ERK/MAPK Pathway, Neurobiology, PKA/PKC Pathway, Ser/Thr Kinases


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