CAMK2D is a serine/threonine protein kinase that is a member of the type II multifunctional Ca2+/calmodulin-dependent protein kinase family. CAMK2D is abundantly present in human cardiac and skeletal muscle and its levels are increased in the heart of patients suffering from cardiomyopathy (1). In cardiomyocytes, stimulation of beta-1-adrenergic receptor leads to induction of apoptosis, an effect that is mediated by activation of CAMK2D in a PKA-independent manner. In addition, expression studies have revealed the downregulation of CAMK2D in human tumor cells.
1. Hoch, B. Et al: Identification and expression of delta-isoforms of the multifunctional Ca(2+)/calmodulin-dependent protein kinase in failing and nonfailing human myocardium. Circ. Res. 84: 713-721, 1999.
2. Zhu, W.-Z. Et al: Linkage of beta-1-adrenergic stimulation to apoptotic heart cell death through protein kinase A-independent activation of Ca(2+)/calmodulin kinase II. J. Clin. Invest. 111: 617-625, 2003.
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
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Cardiovascular Disease, ERK/MAPK Pathway, Neurobiology, PKA/PKC Pathway, Ser/Thr Kinases