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PYK2, Active

Recombinant human PYK2 (360-690) was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag.
Catalog No. P92-11H


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Catalog No. Pack Size Price (USD)
P92-11H-05 5 ug $226
P92-11H-10 10 ug $325
P92-11H-BULK BULK Contact Us  


Overview:

PYK2 (also known as FAK2/RAFTK) is a member of the focal adhesion PTK family. PYK2/FAK2 can be activated by a variety of extracellular signals that elevate intracellular calcium concentration, and by stress signals (1). Unlike FAK, which is widely expressed in various tissues and links transmembrane integrin receptors to intracellular pathways, PYK2/FAK2 is expressed mainly in the central nervous system and in cells derived from hematopoietic lineages. In osteoclasts, although FAK is expressed, PYK2/FAK2 appears to be the predominant mediator of integrin alpha(v)beta3 signaling events that influence osteoclast physiology and pathology (2).


Gene Aliases:

FAK2, PTK2B, CADTK, FADK2, CAKB, PKB, PTK, RAFTK, PYK2


Genbank Number:


References:


1. Avraham, H. et al: RAFTK/Pyk2-mediated cellular signalling. Cell Signal. 2000 Mar;12(3):123-33.

2. Xiong, W C. et al: PYK2 and FAK in osteoclasts. Front Biosci. 2003 Sep 1;8:d1219-26.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~39 kDa



Product Datasheets



RESEARCH AREAS

Cancer, Cardiovascular Disease, Cytoplasmic Tyrosine Kinases, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, JAK/STAT Pathway, Neurobiology


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