RSK2 is a member of the RSK (ribosomal S6 kinase) family that are growth factor-regulated serine/threonine kinases. RSK2 has been shown to mediate growth factor signaling via RAS and MAPK leading to the induction of CREB serine-133 phosphorylation and activation of gene expression (1). Mutations in RSK2 have been shown to be responsible for Coffin-Lowry syndrome (CLS) which is a X-linked disorder characterized by severe psychomotor retardation, facial and digital dysmorphisms, and progressive skeletal deformations (2).
RPS6KA3; HU-3; MAPKAPK1B; CLS; MRX19; ISPK-1; p90-RSK2; pp90RSK2; S6K-alpha3
1. Xing, J. et al: Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase. Science. 1996 Aug 16;273(5277):959-63.
2. Jacquot, S. et al: Mutation analysis of the RSK2 gene in Coffin-Lowry patients: extensive allelic heterogeneity and a high rate of de novo mutations. Am J Hum Genet. 1998 Dec;63(6):1631-40
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Artamonov MV et al., RSK2 contributes to myogenic vasoconstriction of resistance arteries by activating smooth muscle myosin and the Na+/H+ exchanger Science Signaling October 2018 10.1126/scisignal.aar3924
Wesolowska B Nadratowska et al., RSK2 regulates endocytosis of FGF receptor 1 by phosphorylation on serine 789. Oncogene October 2014 10.1038/onc.2013.425
E. Gawecka Joanna et al., RSK2 Suppresses Integrin Activation and Fibronectin Matrix Assembly and Promotes Cell Migration Journal of Biological Chemistry November 2012 10.1074/jbc.M112.423046
L Wang et al., A ERK/RSK-mediated negative feedback loop regulates M-CSF?evoked PI3K/AKT activation in macrophages FASEB Journal October 2017 10.1096/fj.201700672RR
MJ Lommel et al., L-plastin Ser5 phosphorylation breast cancer cells and in vitro is mediated by RSK downstream of the ERK/MAPK pathway. FASEB Journal March 2016 10.1096/fj.15-276311
Yanga Shuping et al., Phosphorylation of KIBRA by the extracellular signal-regulated kinase (ERK)?ribosomal S6 kinase (RSK) cascade modulates cell proliferation and migration Cellular Signaling February 2014 10.1016/j.cellsig.2013.11.012
M. Reipas Kristen et al., Luteolin is a novel p90 ribosomal S6 kinase (RSK) inhibitor that suppresses Notch4 signaling by blocking the activation of Y-box binding protein-1 (YB-1). Oncotarget February 2014 10.18632/oncotarget.834
A. Everley Robert et al., Increasing Throughput in Targeted Proteomics Assays: 54-Plex Quantitation in a Single Mass Spectrometry Run Analytical Chemistry May 2013 10.1021/ac400845e
Apoptosis/Autophagy, Cancer, Cardiovascular Disease, ERK/MAPK Pathway, Inflammation, Neurobiology, NfkB Pathway, Ser/Thr Kinases