Overview:

AFX is a member of the O class of winged helix/forkhead transcription factor family. AFX proteins are involved in cell cycle regulation and inactivation of these proteins help in oncogenic transformation. AFX regulates apoptosis in part by suppressing the level of antiapoptotic BCLX through the transcriptional repressor BCL6 (1). AFX is down-regulated in patients with inflammatory bowel disease. AFX is expressed in human luteinized mural granulosa cells and may be involved in human folliculogenesis and luteinization. AFX acts as a novel anticancer agent for HER2-overexpressing cells.

References:

1. Tang, T. et al: The forkhead transcription factor AFX activates apoptosis by induction of the BCL-6 transcriptional repressor. J. Biol. Chem. 27714255-14265, 2002.