Overview:

Diacylglycerol kinase zeta (DAG kinase zeta) is a member of class IV diacylglycerol kinase family, which contains two zinc fingers, an ATP binding site, and four ankyrin repeats with the MARCKS phosphorylation site, and exhibits the preference for 1,2-diacylglycerols but not for long chain diacylglycerols (1). DGK zeta regulates Ras activation via terminating the diacylglycerol signaling induced RasGRP (2). DGK zeta deficient mice were hyper-responsive to T cell receptor stimulation (3). Also, increased expression levels of DGK zeta promotes Rho GTPase activity and cancer cell invasion (4).

Gene Aliases:

DAGK5; DAGK6; DGK-ZETA; hDGKzeta

Genbank Number:

NM_003646

References:

1. Bunting, M. et al. Molecular Cloning and Characterization of a Novel Human Diacylglycerol Kinase zeta. The Journal of Biological Chemistry. (271) 10230–10236, 1996.

2. Topham, M. et al. Diacylglycerol Kinase zeta Regulates Ras Activation by a Novel Mechanism. The Journal of Cell Biology. (152) 1135–1143, 2001.

3. Zhong X. et al. Enhanced T cell responses due to diacylglycerol kinase ζ deficiency. Nature Immunology. (4) 882-890, 2003.

4. Cai K. et al. Increased diacylglycerol kinase ζ expression in human metastatic colon cancer cells augments Rho GTPase activity and contributes to enhanced invasion. BMC Cancer. (14) 208-217, 2014.