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LIMK2, Active

Recombinant full-length human LIMK2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. L05-10G

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Catalog No. Pack Size Price (USD)
L05-10G-05 5 ug $226
L05-10G-10 10 ug $325
L05-10G-BULK BULK Contact Us  


LIMK2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain (1). LIM domains are highly conserved cysteine-rich structures that can mediate protein-protein interaction. LIMK2 is phosphorylated and activated by ROCK, a downstream effector of Rho, and then LIMK2 in turn phosphorylates cofilin, inhibiting its actin-depolymerizing activity which contributes to Rho-induced reorganization of the actin cytoskeleton (2). LIMK2 is highly expressed in liver, colon, stomach, spleen, brain, kidney, and placenta.

Gene Aliases:


Genbank Number:


1. Okano, I. et.al: Identification and characterization of a novel family of serine/threonine kinases containing two N-terminal LIM motifs. J. Biol. Chem. 270: 31321-31330, 1995.

2. Maekawa, M. et.al: Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase. Science 285: 895-898, 1999.

Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Molecular Weight:

~96 kDa

Product Datasheets

There are no related publications available for this product.


Angiogenesis, Cancer, Cardiovascular Disease, Invasion/Metastasis, Ser/Thr Kinases


  Kinase Dilution Buffer III, K23-09

  Kinase Assay Buffer I, K01-09

  ATP Stock Solution, A50-09

  Cofilin 1 Protein, C37-54H



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