Overview:

The angiotensin converting enzyme 2 (ACE2) belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases (1). ACE2 cleaves the angiotensin I and angiotensin II to counterbalancing ACE activity in the regulation of renin angiotensin system (RAS) (1). ACE2 also has the role in regulation of cardiovascular, renal and reproductive systems physiologically (1). In addition, ACE2 is a functional receptor for the spike glycoprotein (S) of SARS-CoV, HCoV-NL63, and SARS-CoV-2 (2), which causes the pandemic of the respiratory diseases (COVID-19) (3).

Gene Aliases:

ACE-related carboxypeptidase

Genbank Number:

NM_001012006

References:

1. Imai Y, et al: Angiotensin-converting enzyme 2 (ACE2) in disease pathogenesis. Circ J. 2007, 74(3):405-10.

2. Lan J, et al: Crystal structure of the 2019-nCov spike receptor-binding domain bound with the ACE2 receptor. bioRxiv. doi: https://doi.org/10.1101/2020.02.19.956235.

3. Zhou P, et al: A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020, 579:270-89.