Overview:

HCK, a protein-tyrosine kinase belonging to the Src family, is expressed in certain hemopoietic cells and especially prominent in cells of myeloid lineage, particularly mature granulocytes and monocytes (1). HCK gene is located on chromosome sequence 20q11-q12, a region that is affected by interstitial deletions in some acute myeloid leukemias and myeloproliferative disorders suggesting damage to HCK may contribute to the pathogenesis of these conditions (2).

Gene Aliases:

JTK9

Genbank Number:

NM_002110

References:

1. Ziegler, S F. et al: Novel protein-tyrosine kinase gene (hck) preferentially expressed in cells of hematopoietic origin. Molec. Cell. Biol. 7: 2276-2285, 1987.

2. Quintrell, N. et al: Identification of a human gene (HCK) that encodes a protein-tyrosine kinase and is expressed in hemopoietic cells. Molec. Cell. Biol. 7: 2267-2275, 1987