Recombinant full-length human STAT4 was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag.
Catalog No. S55-54H
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| S55-54H-20 | 20 ug | $215 | |
| S55-54H-50 | 50 ug | $435 | |
| S55-54H-BULK | BULK | Contact Us |
Overview:
STAT4 (signal transducer and activator of transcription 4) is a member of the STAT family that is phosphorylated by receptor-associated protein kinases. STATs form homo- or heterodimers and translocate to the cell nucleus where they act as transcription activators. T helper (Th) cells differentiation is regulated by STAT4 (1). STAT4 controls T1/T2 balance during the response to live influenza virus and isolated viral proteins. The differentiation of gamma interferon (IFN-γ)-producing Th1 and Tc1 cells after inoculation of live virus occurred independently of STAT4 expression. STAT4 has been shown to control pathogenesis of chronic obstructive pulmonary disease (2).
Genbank Number:
References:
1. Andrea L W. et al: The biology of Stat4 and Stat6. Oncogene, 2000,19: 21, 2577-2584.
2. Cosio. G M.: Autoimmunity, T-cells and STAT-4 in the pathogenesis of chronic obstructive pulmonary disease. Eur Respir J, 2004; 24:3-5.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~87 kDa
There are no related publications available for this product.
Apoptosis/Autophagy, Cancer, ERK/MAPK Pathway, Inflammation, JAK/STAT Pathway
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