EGFR inhibitor
Catalog No. E10-900B
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| E10-900B-05 | 5 mg | $75 | |
| E10-900B-25 | 25 mg | $225 | |
| E10-900B-BULK | BULK | Contact Us |
Overview:
Potent and selective inhibitor of the EGFR kinase IC50 = 3 nM. Inhibits proliferation of a variety human cancer cell lines (1,2). Reduces pulmonary fibrosis in a rat model (3). Cell permeable.
References:
1. Y Han et al. Cancer. Res.1996 56:3859
2. G Partik et al. J. Cancer Res. Clin. Oncol.1999 125:379
3. AB Rice et al. Am. J. Pathol. 1999 155:213
CAS Registry Number:
175178-82-2
Molecular Formula:
C16H14ClN3O2
Appearance:
Off white powder
Melting Point:
177-178oC
Molecular Weight:
315.8
Purity:
>98% (TLC); NMR (Conforms)
Solubilization:
May be dissolved in DMSO (30 mg/ml); or Ethanol (10 mg/ml, warm)
Aliases:
1. N-(3-Chlorophenyl)-6,7-dimethoxy-4-quinazolinanine
2. Free Base
Storage and Stability:
Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 2 months.
Molecular Structure:
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There are no related publications available for this product.
AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, Metabolic Disorder, PKA/PKC Pathway, Receptor Tyrosine Kinases
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