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PRKG1, Active

Recombinant full-length human PRKG1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. P78-10BG


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Catalog No. Pack Size Price (USD)
P78-10BG-05 5 ug $226
P78-10BG-10 10 ug $325
P78-10BG-BULK BULK Contact Us  


Overview:

PRKG1 is a homodimer, with each monomer containing a regulatory cGMP-binding domain and a catalytic domain (1). By Northern blot analysis PRKG1 was shown to be expressed at highest levels in bladder, uterus, adrenal gland, and fallopian tube. PRKG1 plays an important stimulatory role in platelet activation (2). Expression of recombinant PRKG1 in a reconstituted cell model enhanced von Willebrand factor-induced activation of the platelet integrin alpha-IIb/beta-3. Prkg1 knockout mice showed impaired platelet responses to VWF or low doses of thrombin and prolonged bleeding time. Human platelet aggregation induced by VWF or low-dose thrombin was inhibited by PRKG1 inhibitors but enhanced by cGMP.


Gene Aliases:

PGK, CGKI, PRKG1B, PRKGR1B, FLJ36117, MGC71944, cGKI-BETA, cGKI-alpha, DKFZp686K042


Genbank Number:


References:


1. Orstavik, S. et al: Characterization of the human gene encoding the type I-alpha and type I-beta cGMP-dependent protein kinase (PRKG1). Genomics 42: 311-318, 1997.

2. Li, Z. et al: A stimulatory role for cGMP-dependent protein kinase in platelet activation. Cell 112: 77-86, 2003.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~100 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cardiovascular Disease, Neurobiology, NfkB Pathway, PKA/PKC Pathway, Ser/Thr Kinases


RELATED PRODUCTS


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