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Cyclin T2 Protein

Full-length recombinant human Cyclin T2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. C86-30BG


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Catalog No. Pack Size Price (USD)
C86-30BG-20 20 ug $215
C86-30BG-50 50 ug $435
C86-30BG-BULK BULK Contact Us  


Overview:

Cyclin T2 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle which function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclin T2 and its kinase partner CDK9 were found to be subunits of the transcription elongation factor p-TEFb. The p-TEFb complex containing this cyclin was reported to interact with, and act as a negative regulator of human immunodeficiency virus type 1 (HIV-1) Tat protein(1). In mammalian cells, all 3 CDK9/cyclin T combinations strongly activated a CMV promoter(2).


Gene Aliases:

CCNT2; CYCT2


Genbank Number:


References:


1. Yang, Z.et.al: The 7SK small nuclear RNA inhibits the CDK9/cyclin T1 kinase to control transcription. Nature 414: 317-322, 2001.

2. Peng, J.et.al: Identification of multiple cyclin subunits of human P-TEFb. Genes Dev. 12: 755-762, 1998.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~102 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cell Cycle


RELATED PRODUCTS


  CyclinH Protein, C83-30H

  CyclinK Protein, C84-30G

  CDK9/CyclinT2, Active, C40-18BG

  PCTK2 (CDK17)/CyclinY, Active, P10-10G


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