Overview:

MGRN1 or mahogunin ring finger 1, E3 ubiquitin protein ligase is a C3HC4 RING-containing protein with E3 ubiquitin ligase activity in vitro (1). MGRN1 gene encodes 4 mRNA isoforms that contain a central C3HC4 RING domain as the only recognizable protein motif and regions flanking the RING domain and the N-terminal region of the protein are also conserved between vertebrate and invertebrate genome and MGRN1 is highly expressed in brain (2). MGRN1 has been detected in the adrenal cortex in kidney and its role may relate to the trafficking and/or degradation of the melanocortin 2 receptor.

Gene Aliases:

CD41B, GP2B, ITGA2B, KIAA0544, RNF156

Genbank Number:

NM_015246

References:

1. Phan, L. K.et.al: The mouse mahoganoid coat color mutation disrupts a novel C3HC4 RING domain protein. J. Clin. Invest. 110: 1449-1459, 2002.

2. He, L. et.al: Spongiform degeneration in mahoganoid mutant mice. Science 299: 710-712, 2003.