MNK1 (MAP kinase-interacting kinase 2) is a MAP kinase interacting serine/threonine kinase 1 that isolated by a novel expression screening method for identifying the protein kinase substrates (1). Mnk1 expressed in all tissues with the highest level of expression in skeletal muscle (2).
1. Fukunaga, R. et.al: MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates. EMBO J. 16: 1921-1933, 1997.
2. Waskiewicz, A. J. et.al: Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2. EMBO J. 16: 1909-1920, 1997.
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
JB Bell et al., Differential Response of Glioma Stem Cells to Arsenic Trioxide Therapy is Regulated by MNK1 and mRNA Translation Mol Cancer Res October 2017 10.1158/1541-7786.MCR-17-0397
B Bell Jonathan et al., Differential Response of Glioma Stem Cells to Arsenic Trioxide Therapy is Regulated by MNK1 and mRNA Translation Mol Cancer res 10.1158/1541-7786.MCR-17-0397
Angiogenesis, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, p38 Pathway, Ser/Thr Kinases