Recombinant human ERN1 (IRE1) (468-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. E31-11G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
E31-11G-05 | 5 ug | $226 | |
E31-11G-10 | 10 ug | $325 | |
E31-11G-BULK | BULK | Contact Us |
Overview:
ERN1 or endoplasmic reticulum to nucleus signaling 1 is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product which possesses intrinsic kinase activity and an endoribonuclease activity and it is important in endoplasmic reticulum-based stress signals. ERN1 controls IRE1 proteolysis in mammalian cells (1). The activation of ERN1 through oligomerization expands the mechanistic repertoire of kinase-based signaling receptors. ERNI has a critical function in extraembryonic cells that is essential for fetal viability (2).
Gene Aliases:
hIRE1p; IRE1; IRE1A; IRE1P
Genbank Number:
References:
1. Niwa, M.et.al: A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response. Cell 99: 691-702, 1999.
2. Iwawaki, T.et.al: Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability. Proc. Nat. Acad. Sci. 106: 16657-16662, 2009.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~87 kDa
JM Wang et al., Inositol Requiring Enzyme 1 Facilitates Diabetic Wound Healing through Modulating microRNAs. Diabetes September 2016 10.2337/db16-0052
JM Wang et al., Inositol-requiring enzyme 1 facilitates diabetic wound healing through modulating microRNAs Diabetes J January 2017 10.2337/db16-0052
Ravanan P et al., IRE 1α is critical for Kaempferol‐induced neuroblastoma differentiation
The FEBS journal April 2019 10.1111/febs.14776
et al., GABA and Fermented Curcuma longa L. Extract Enriched with GABA Ameliorate Obesity through Nox4-IRE1? Sulfonation-RIDD-SIRT1 Decay Axis in High-Fat Diet-Induced Obese Mice Nutrients April 2022
et al., Ameliorating Methylglyoxal-Induced Progenitor Cell Dysfunction for Tissue Repair in Diabetes Diabetes June 2019
Angiogenesis, Cellular Stress, Neurobiology, Ser/Thr Kinases
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