Overview:

The Serine/threonine protein kinase ataxia-telangiectasia mutated (ATM) is an atypical kinase of the phosphoinositide 3-kinase (PI3K)-related protein kinase PIKK family, which also includes ATM and Rad3-related protein (ATR), the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs), hSMG1, and mammalian target of rapamycin (mTOR) kinases (1). It plays a prominent role as an apical activator of the DNA damage response under the circumstance of DNA double-strand breaks (DSBs). Following induction of DSBs, ATM mobilizes one of the most extensive signaling networks that responds to specific stimuli and modifies directly or indirectly a broad range of targets (2).

Gene Aliases:

AT1, ATA, ATC, ATD, ATE, ATDC, TEL1, MGC74674

Genbank Number:

NM_000051

References:

1. Lempiäinen H, Halazonetis TD. Emerging common themes in regulation of PIKKs and PI3Ks. EMBO J. 2009 Oct 21;28(20):3067-73.

2. Shiloh Y, Ziv Y. The ATM protein kinase: regulating the cellular response to genotoxic stress, and more. Nat Rev Mol Cell Biol. 2013 Apr;14(4):197-210.