Full-length recombinant human ERK4 (MAPK4) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. M30-34G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| M30-34G-20 | 20 ug | $215 | |
| M30-34G-50 | 50 ug | $435 | |
| M30-34G-BULK | BULK | Contact Us |
Overview:
Extracellular signal-regulated kinase 4 (ERK4) is a serine/threonine protein kinase and belongs to atypical MAPKs. Among MAPKs, it is most closely related to the MAP kinase ERK3, with 73% amino acid identity within the kinase catalytic domain. The precise role of ERK4 is still unclear. It phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5, and may promote entry in the cell cycle.
Gene Aliases:
MAPK4; ERK3; p63MAPK; PRKM4
Genbank Number:
References:
1. Rousseau J, et al. Targeted inactivation of Mapk4 in mice reveals specific nonredundant functions of Erk3/Erk4 subfamily mitogen-activated protein kinases. Mol Cell Biol. 30:5752-63, 2010
2. Kostenko S, et al. Tumour promoting and suppressing roles of the atypical MAP kinase signalling pathway ERK3/4-MK5. J Mol Signal. 7:9, 2012.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~110 kDa
Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, ERK/MAPK Pathway, Invasion/Metastasis, Neurobiology, Ser/Thr Kinases
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Bhandaria Deepali et al., Cyclin-dependent kinase 5 activates guanine nucleotide exchange factor GIV/Girdin to orchestrate migration?proliferation dichotomy PNAS July 2015 10.1073/pnas.1514157112 
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