Overview:

CDK11A or cyclin-dependent kinase 11A is a member of the p34Cdc2 protein kinase family. CDKs are known to be essential for eukaryotic cell cycle control. CDK11A gene complex may harbor one or more tumor suppressor genes affected by chromosome 1p36 modifications in neuroblastoma (1). CDK11A is associated with the alpha and beta isoforms of cyclin L1 and L2 in a high molecular mass complex that shows splicing activity (2). CDK11A can be cleaved by caspases and this is demonstrated to play a role in cell apoptosis.

Gene Aliases:

CDK11A: CDC2L2; CDC2L3; CDK11-p110; CDK11-p46; CDK11-p58; p58GTA; PITSLRE
CyclinD3: CCND3

Genbank Number:

NM_024011
NM_001760

References:

1. Lahti, J. M. et.al: Alterations in the PITSLRE protein kinase gene complex on chromosome 1p36 in childhood neuroblastoma. Nature Genet. 7: 370-375, 1994.

2. Loyer, P. et.al: Characterization of cyclin L1 and L2 interactions with CDK11 and splicing factors: influence of cyclin L isoforms on splice site selection. J. Biol. Chem. 283: 7721-7732, 2008.