Home   >    Enzymes   >   Kinases

IRR, Active

Recombinant human IRR (945-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. I07-11G


Shop Online



Catalog No. Pack Size Price (USD)
I07-11G-05 5 ug $226
I07-11G-10 10 ug $325
I07-11G-BULK BULK Contact Us  


Overview:

IRR or insulin receptor-related receptor is a tyrosine protein kinase that is required for the appearance of male gonads and thus for male sexual differentiation (1). The expression of IRR mRNA is restricted to a few tissue types and has been detected in neuronal tissues as well as in neuroblastomas. As a result of its occurrence in neuroblastomas, it has speculated that IRR may be involved in tumor genesis. RT-PCR and solution hybridization/RNAse protection assay have shown strong coupling of IRR mRNA in 18 tumor cell lines (2).


Gene Aliases:

INSRR


Genbank Number:


References:


1. Zhang, B. and Roth, R.A. The insulin receptor-related receptor. Tissue expression, ligand binding specificity, and signaling capabilities. J. Biol. Chem. 1992; 267 (26): 18320-8.

2. Elmlinger, M.W. et al: Correlation of type I insulin-like growth factor receptor (IGF-I-R) and insulin receptor-related receptor (IRR) messenger RNA levels in tumor cell lines from pediatric tumors of neuronal origin. Regul. Pept., 1999; 84 (1-3): 37-42.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~65 kDa



Product Datasheets



Safety Datasheet



RESEARCH AREAS

AKT/PKB Pathway, Cancer, Cellular Stress, ERK/MAPK Pathway, Receptor Tyrosine Kinases


RELATED PRODUCTS


  IGF1R, Active, I02-11H

  InsR, Active, I08-11G

  ATP Stock Solution, A50-09

  Kinase Assay Buffer II, K02-09


SIGNALCHEM BIOTECH INC.


About

Terms of Service

Privacy Policy

Get the latest resources, updates and offers in your inbox