Overview:

LRRK1, also called leucine-rich repeat kinase 1, is highly expressed in testis, placenta, prostate, and muscle, with moderate expression in brain, pancreas, small intestine, stomach, and spleen. Mutations in LRRK1 corresponding to Parkinson disease-8 -associated mutations found in LRRK2, significantly reduced LRRK1 kinase activity (1). LRRK1 expression in all mouse brain regions examined, with highest expression in olfactory bulb (2). LRRK1 functions as a GDP/GTP-binding protein and its kinase activity is stimulated upon binding of GTP to the ROC domain.

Gene Aliases:

RIPK6; Roco1; FLJ23119; KIAA1790

Genbank Number:

NM_024652

References:

1. Korr, D.et.al: LRRK1 protein kinase activity is stimulated upon binding of GTP to its Roc domain. Cell. Signal. 18: 910-920, 2006.

2. Taylor, J. P.et.al: Leucine-rich repeat kinase 1: a paralog of LRRK2 and a candidate gene for Parkinson's disease. Neurogenetics 8: 95-102, 2007