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RSK4, Active

Recombinant full-length human RSK4 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. R20-10G


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Catalog No. Pack Size Price (USD)
R20-10G-05 5 ug $226
R20-10G-10 10 ug $325
R20-10G-BULK BULK Contact Us  


Overview:

RSK4 is a member of the 90-kDa ribosomal S6 kinase family which are important components of growth factor mediated stimulation of cellular proliferation, survival and differentiation. RSK4 is activated via coordinated phosphorylation by ERK and 3-phosphoinositide-dependent protein kinase-1 (PDK1) (1). RSK4 is often associated with contiguous gene syndromes consisting of X-linked deafness type 3 (DFN3), mental retardation (MRX) and choroideremia (CHM). RSK4 is most abundantly expressed in the brain and kidney (2).


Gene Aliases:

RPS6KA6


Genbank Number:


References:


1. Yntema, H.G. et al:, A novel ribosomal S6-kinase (RSK4; RPS6KA6) is commonly deleted in patients with complex X-linked mental retardation. Genomics. 1999 ;15;62(3):332-43

2. Bettina, A. et al: Functional Characterization of Human RSK4, a New 90-kDa Ribosomal S6 Kinase, Reveals Constitutive Activation in Most Cell Types. J. Biol. Chem., 2005; 280, Issue 14,13304-13314


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~112kDa



Product Datasheets



Safety Datasheet



RESEARCH AREAS

Apoptosis/Autophagy, Cancer, Cardiovascular Disease, ERK/MAPK Pathway, Inflammation, Neurobiology, NfkB Pathway, Ser/Thr Kinases


RELATED PRODUCTS


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  ERK1, Active, M29-10U

  RSK Substrate, S06-58

  BRD-7389, R15-901


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