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ULK2, Active

Recombinant human ULK2 (1-478) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. U02-11G


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Catalog No. Pack Size Price (USD)
U02-11G-05 5 ug $259
U02-11G-10 10 ug $380
U02-11G-BULK BULK Contact Us  


Overview:

ULK2 is a serine/threonine protein kinase that plays critical role during initial stages of autophagy which is a vital response to nutrient starvation. Mammalian Atg13 binds ULK2 and mediates the interaction of the ULK protein with FIP200. The binding of Atg13 stabilizes and activates ULK and facilitates the phosphorylation of FIP200 by ULK. The ULK-Atg13-FIP200 complex is a direct target of mTOR and important regulator of autophagy in response to mTOR signalling (1). Yeast 2-hybrid assays showed the C-terminus of ULK2 binds the C-terminus of SynGAP, a negative regulator of Ras that is associated with neural development (2).


Gene Aliases:

Unc51.2, KIAA0623


Genbank Number:


References:


1. Jung C H, et al: ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. Mol Biol Cell. 2009 Apr;20(7):1992-2003.

2. Tomoda T, et al: Role of Unc51.1 and its binding partners in CNS axon outgrowth. Genes Dev. 18: 541-558, 2004.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~98 kDa



RESEARCH AREAS

Apoptosis/Autophagy, Cancer, Ser/Thr Kinases


RELATED PRODUCTS


  ULK1, Active, U01-11G

  ULK3, Active, U03-10H

  ULK4 Protein, U04-35G


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