Full length recombinant human IKK alpha was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. C51-10G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
C51-10G-05 | 5 ug | $226 | |
C51-10G-10 | 10 ug | $325 | |
C51-10G-BULK | BULK | Contact Us |
Overview:
IKKα is a serine/threonine protein kinase that phosphorylates the I-kappa-B protein which is an inhibitor of the transcription factor NF-kappa-B complex. Phosphorylation of I-kappa-B protein triggers the degradation of the inhibitor via the ubiquitination pathway, thereby activating NF-kappa-B complex (1). IKKα is an essential regulator of NF-kappa-B-dependent gene expression through control of promoter-associated histone phosphorylation after cytokine exposure (2). IKKα is a critical component of the cytoplasmic transductional-transcriptional processor leading to induction of IFNα production. IKKα is also involved in the epidermis where it antagonizes mitogenic and angiogenic signals and represses tumor progression and metastases.
Gene Aliases:
CHUK, IKK1, IKBKA, TCF16, NFKBIKA, IKK-alpha
Genbank Number:
References:
1. Anest, V.et.al: A nucleosomal function for I-kappa-B kinase-alpha in NF-kappa-B-dependent gene expression. Nature 423: 659-663, 2003.
2. Hoshino, K. et.al: I-kappa-B kinase-alpha is critical for interferon-alpha production induced by Toll-like receptors 7 and 9. Nature 440: 949-953, 2006.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~114 kDa
AKT/PKB Pathway, Apoptosis/Autophagy, Inflammation, p38 Pathway
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