Recombinant full-length human VRK1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. V01-10G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| V01-10G-05 | 5 ug | $226 | |
| V01-10G-10 | 10 ug | $325 | |
| V01-10G-BULK | BULK | Contact Us |
Overview:
VRK1 is a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. VRK1 is widely expressed in human tissues and actively dividing cells, such as those in testis, leukocytes, fetal liver and carcinomas. VRK1 regulate cell proliferation and phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN. The spinal muscular atrophy with pontocerebellar hypoplasia is caused by a mutation in the VRK1 gene.
Gene Aliases:
MGC117401; MGC138280; MGC142070
Genbank Number:
References:
1. Nezu, J. et.al: Identification of two novel human putative serine/threonine kinases, VRK1 and VRK2, with structural similarity to vaccinia virus B1R kinase. Genomics 45: 327-331, 1997.
2. Renbaum, P. et.al: Spinal muscular atrophy with pontocerebellar hypoplasia is caused by a mutation in the VRK1 gene. Am. J. Hum. Genet. 85: 281-289, 2009.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
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Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~71 kDa
There are no related publications available for this product.
Apoptosis/Autophagy, Cancer, ERK/MAPK Pathway, JNK/SAPK Pathway, p38 Pathway, Ser/Thr Kinases
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