Overview:

NLK (also known as nemo-like kinase) is a member of the serine/threonine protein kinase that is encoded by the NLK gene. NLK plays a role in cell fate determination and is required for the differentiation of bone marrow stromal cells. NLK also suppresses a wide range of transcription factors such as CREB by phosphorylation of the co-activator CREBBP. NLK expression increases the number of apoptotic cells but does not induce obvious cell cycle arrest (1). NLK suppresses Notch signalling by interfering with formation of the Notch active transcriptional complex (2).

Gene Aliases:

FLJ21033, DKFZp761G1211

Genbank Number:

NM_016231

References:

1. Yasuda, J. et.al: Nemo-like kinase induces apoptosis in DLD-1 human colon cancer cells. Biochem. Biophys. Res. Commun. 308: 227-233, 2003.

2. Ishitani T, et.al:. NLK suppresses the Notch signalling pathway. Nat Cell Biol, 2010 Mar.