Overview:

SRMS is a Src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites that is involved in proliferation or differentiation of keratinocytes in the skin. SRMS functions as a rapid downstream signaling intermediate following calcium-induced differentiation in keratinocytes. SRMS constitutes a new family of non-receptor tyrosine kinases that may be redundant in function (1). SRMS can act either in the membrane or at the nucleus, and may change localization patterns depending on external stimuli.

Gene Aliases:

SRM, C20orf148, dJ697K14.1

Genbank Number:

NM_080823

References:

1. Kohmura N. et.al: "A novel nonreceptor tyrosine kinase, Srm: cloning and targeted disruption." Mol. Cell. Biol. 14:6915-6925,1994.