Enzymes, Signaling Proteins, Extracellular Ligands, Signaling Reagents, Antibodies

Catalog No.	Pack Size	Price (USD)
A16-14G-20	20 ug	$215
A16-14G-50	50 ug	$435
A16-14G-BULK	BULK	Contact Us

Overview:

AKT1/PKBα is a serine/threonine kinase that belongs to the AKT family. AKT1 is activated in cells in response to diverse stimuli such as hormones, growth factors and extracellular matrix components and is involved in glucose metabolism, transcription, survival, cell proliferation, angiogenesis, and cell motility (1). AKT1 is frequently overexpressed and active in many types of human cancers including cancers of colon, breast, brain, pancreas and prostate as well as lymphomas and leukemias (2).

Gene Aliases:

PKB; RAC; PRKBA; MGC99656; RAC-ALPHA

Genbank Number:

NM_005163

References:

1. Coffer, PJ. et al: Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation. Biochem J. 1998 Oct 1; 335 (Pt 1): 1-13.

2. Anderson, KE. et al: Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B. Curr Biol. 1998 Jun 4;8(12): 684-91.

Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping:

Store product at –70^oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Molecular Weight:

~85 kDa

Product Datasheets

Q187-2

F460-1

Z4882-3

Ghosh Dastidar Somasish et al., FoxG1 Promotes the Survival of Postmitotic Neurons Journal of Neuroscience January 2011 10.1523/JNEUROSCI.2897-10.2011

Cena Bo et al., The Pim-1 protein kinase is an important regulator of MET receptor tyrosine kinase levels and signaling Molecular and Cellular Biology March 2014 10.1128/MCB.00147-14

Lamouille Samy et al., TGF-?-induced activation of mTOR complex 2 drives epithelial?mesenchymal transition and cell invasion Journal of Cell Science March 2012 10.1242/jcs.095299

Zenga in et al., Lanthionine synthetase C-like protein 2 (LanCL2) is a novel regulator of Akt Molecular Biology of the Cell September 2014 10.1091/mbc.E14-01-0004

Cennia Vittoria et al., Ankrd2/ARPP is a novel Akt2 specific substrate and regulates myogenic differentiation upon cellular exposure to H2O2 Molecular Biology of the Cell July 2011 10.1091/mbc.E10-11-0928

Zhang Chongben et al., Inhibited insulin signaling in mouse hepatocytes is associated with increased phosphatidic acid but not diacylglycerol Journal of Biological Chemistry December 2014 10.1074/jbc.M114.602789

Ling Dai Chun et al., Inhibition of Protein Synthesis Alters Protein Degradation through Activation of Protein Kinase B (AKT) Journal of Biological Chemistry July 2013 10.1074/jbc.M112.445148

Fukuda Koichi et al., Biochemical, Proteomic, Structural, and Thermodynamic Characterizations of Integrin-linked Kinase (ILK) CROSS-VALIDATION OF THE PSEUDOKINASE* Journal of Biological Chemistry June 2011 10.1074/jbc.M111.240093

Bavelloni Alberto et al., Prohibitin 2 represents a novel nuclear AKT substrate during all-trans retinoic acid-induced differentiation of acute promyelocytic leukemia cells FASEB Journal February 2014 10.1096/fj.13-244368

Pecorari Luisa et al., Elongation Factor 1 alpha interacts with phospho-Akt in breast cancer cells and regulates their proliferation, survival and motility Molecular Cancer August 2009 10.1186/1476-4598-8-58

M. Singel Stina et al., KIF14 Promotes AKT Phosphorylation and Contributes to Chemoresistance in Triple-Negative Breast Cancer Neoplasia March 2014 10.1016/j.neo.2014.03.008

Zhang Chongben et al., Glycerol-3-phosphate acyltransferase-4-deficient mice are protected from diet-induced insulin resistance by the enhanced association of mTOR and rictor American Journal of Physiology - Endocrinology and Metabolism August 2014 10.1152/ajpendo.00034.2014

Treebak Jonas et al., Identification of a novel phosphorylation site on TBC1D4 regulated by AMP-activated protein kinase in skeletal muscle American Journal of Physiology - Cell Physiology November 2009 10.1152/ajpcell.00297.2009

SC Stolze et al., Photo-crosslinking of clinically relevant kinases using H89-derived photo-affinity probes Molecular BioSystems May 2016 10.1039/c6mb00257a

Asakura Keisuke et al., The Cytostatic Effects of Lovastatin on ACC-MESO-1 Cells Journal of Surgical Research October 2011 10.1016/j.jss.2011.06.037

AKT1, Unactive

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