Overview:

AATK or apoptosis-associated tyrosine kinase contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. AATK is induced during apoptosis, and expression of this protein is a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells (1). AATK is highly detected in brain, lung, kidney, and pancreas (2). AATK is also shown to produce neuronal differentiation in a neuroblastoma cell line.

Gene Aliases:

AATYK; LMTK1; KIAA0641

Genbank Number:

NM_007377

References:

1. Gaozza, E. et.al: AATYK: a novel tyrosine kinase induced during growth arrest and apoptosis of myeloid cells. Oncogene 15: 3127-3135, 1997.

2. Ishikawa, K. et.al: Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. DNA Res. 5: 169-176, 1998.