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HIPK2, Active

Recombinant mouse HIPK2 (153-564) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. H04-11G


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Catalog No. Pack Size Price (USD)
H04-11G-05 5 ug $226
H04-11G-10 10 ug $325
H04-11G-BULK BULK Contact Us  


Overview:

HIPK2 is a conserved serine/threonine nuclear kinase that interacts with homeodomain transcription factors. HIPK2 enhances expression of p53 target genes that resulting in growth arrest and the enhancement of UV-induced apoptosis that could be inhibited by antisense to HIPK2 (1). HIPK2 as a target for MDM2 mediated ubiquitin-dependent degradation that only occurred in growth-arresting conditions when MDM2 was efficiently induced by p53 (2). The knockdown of HIPK2 using small interfering RNA reduced p53 binding and activation of p53R2 that resulting in impaired UV-induced DNA repair.


Gene Aliases:

Stank; 1110014O20Rik; B230339E18Rik


Genbank Number:


References:


1. Hofmann, T. G. et.al: Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2. Nature Cell Biol. 4: 1-10, 2002.

2. Rinaldo, C. et.al: MDM2-regulated degradation of HIPK2 prevents p53Ser46 phosphorylation and DNA damage-induced apoptosis. Molec. Cell 25: 739-750, 2007.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~72 kDa



Product Datasheets



Safety Datasheet



RESEARCH AREAS

Cancer, Cell Cycle, Metabolic Disorder, Ser/Thr Kinases, WNT Signaling


RELATED PRODUCTS


  HIPK1, Active, H03-11G

  HIPK3, Active, H05-13H

  HIPK4, Active, H06-10G


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