Recombinant full length human CRKL was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag.
Catalog No. C53-30H
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| C53-30H-20 | 20 ug | $160 | |
| C53-30H-50 | 50 ug | $336 | |
| C53-30H-BULK | BULK | Contact Us |
Overview:
CRKL or v-crk sarcoma virus CT10 oncogene homolog (avian)-like is a protein kinase containing SH2 and SH3 (src homology) domains that activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion (1). It is a substrate of the BCR-ABL tyrosine kinase which plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic (2). CRKL is also required for normal cellular responses to Fgf8, including survival and migration, Erk activation, and target gene expression.
Gene Aliases:
crk-like protein
Genbank Number:
References:
1. Ten Hoeve.J et.al: Isolation and chromosomal localization of CRKL, a human crk-like gene. Oncogene 8: 2469-2474, 1993.
2. Senechal, K. et.al: The CRKL adaptor protein transforms fibroblasts and functions in transformation by the BCR-ABL oncogene. J. Biol. Chem. 38: 23255-23261, 1996.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~39kDa
Apoptosis/Autophagy, Cancer, Cell Cycle, Receptor Tyrosine Kinases, WNT Signaling
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