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TRKA, Active

Recombinant human TRKA (440-end) was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Catalog No. N16-11G


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Catalog No. Pack Size Price (USD)
N16-11G-05 5 ug $226
N16-11G-10 10 ug $325
N16-11G-BULK BULK Contact Us  


Overview:

TRKA is a member of the trk proto-oncogene family and encodes a 140-kilodalton, membrane-spanning protein tyrosine kinase that is the functional receptor for nerve growth factor (NGF). NGF elicits the rapid phosphorylation of gp140trk on tyrosine residues leading to increased c-Fos expression, DNA synthesis and morphologic transformation (1). A decreased expression of TRKA on the striatal cholinergic neurons has been observed which may contribute, when it reaches a crucial threshold, to the death of cholinergic neurons observed in Alzheimer disease (2).


Gene Aliases:

NTRK1; MTC; TRK; TRK1; p140-TrkA; DKFZp781I14186


Genbank Number:


References:


1. Kaplan, D R. et al: The trk proto-oncogene product: a signal transducing receptor for nerve growth factor. Science. 1991 Apr 26;252(5005):554-8.

2. Boissiere, F. et al: Neurotrophin receptors and selective loss of cholinergic neurons in Alzheimer disease. Mol Chem Neuropathol. 1996 May-Aug;28(1-3):219-23.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~66 kDa



RESEARCH AREAS

Neurobiology, Receptor Tyrosine Kinases


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