Overview:

DYRK3 or dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 is belongs to the DYRK family of dual-specificity protein kinases that catalyze autophosphorylation on serine/threonine and tyrosine residues. DYRK3 expressed in E. coli undergoes tyrosine autophosphorylation and catalyzes phosphorylation of histones H3 and H2B in vitro (1). DYRK3 regulate different steps of the caveolar cycle (2). DYRK3 can promote cell survival through phosphorylation and activation of SIRT1. DYRK3 directly phosphorylate SIRT1 at Thr(522), promoting deacetylation of p53.

Gene Aliases:

RED, REDK, DYRK5

Genbank Number:

NM_001004023

References:

1. Becker, W. et. al : Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases. J. Biol. Chem. 273: 25893-25902, 1998.

2. Pelkmans. L. et.al: Kinase-regulated quantal assemblies and kiss-and-run recycling of caveolae. Nature 436: 128-133, 2005.