Overview:

CDC2L1 is a member of the p34Cdc2 protein kinase family. p34Cdc2 protein kinase family is known to be essential for eukaryotic cell cycle control. CDC2L1 is well conserved evolutionarily and is regulated during murine embryogenesis. CDC2L1 activity is coordinately regulated with that of p34 (cdc2) during the cell cycle (1). The protein kinase encoded by CDC2L1 can be cleaved by caspases and is demonstrated to play roles in cell apoptosis (2).

Gene Aliases:

CDC2L1; CDK11-p110; CDK11-p46; p58CDC2L1; CLK-1; CDK11-p58; p58CLK-1; p58; PK58

Genbank Number:

NM_033486

References:

1. Bunnell, B. et.al: Elevated expression of a p58 protein kinase leads to changes in the CHO cell cycle. Proc. Nat. Acad. Sci. 87: 7 Note: Erratum: Proc. Nat. Acad. Sci. 88: 2612 only, 1991.

2. Xiang, J. et.al: Molecular cloning and expression of alternatively spliced PITSLRE protein kinase isoforms. J. Biol. Chem. 269: 15786-15794, 1994.