Recombinant full-length mouse AURORA A was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. A28-10G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| A28-10G-05 | 5 ug | $226 | |
| A28-10G-10 | 10 ug | $325 | |
| A28-10G-BULK | BULK | Contact Us |
Overview:
AURORA A belongs to a multigenic family of mitotic serine/threonine kinases which are involved in the control of chromosome segregation. AURORA A is involved in centrosome separation, duplication and maturation as well as in bipolar spindle assembly and stability (1). AURORA A is expressed and active at the highest level during G2-M phase of the cell cycle. Overexpression of AURORA A has been found to be correlated with the grade of various human solid tumours. Ectopic AURORA A overexpression in any culture cell line leads to polyploidy and centrosome amplification (2).
Gene Aliases:
IAK; Ark1; Ayk1; STK6; AIRK1; AU019385; AW539821; STK15; AURKA; AIK; AURA; BTAK; AURORA2
Genbank Number:
References:
1. Dutertre, S. et al: On the role of aurora-A in centrosome function. Oncogene. 2002 Sep 9;21(40):6175-83.
2. Katayama, H. et al: The Aurora kinases: role in cell transformation and tumorigenesis. Cancer Metastasis Rev. 2003 Dec;22(4):451-64.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
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Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~71 kDa
Jian-Fu Chen et al., Microcephaly disease gene Wdr62 regulates mitotic progression of embryonic neural stem cells and brain size Nature Communications May 2015 10.1038/ncomms4885
C.Thakur Harish et al., The Centrosomal Adaptor TACC3 and the Microtubule Polymerase chTOG Interact via Defined C-terminal Subdomains in an Aurora-A Kinase-independent Manner Journal of Biological Chemistry January 2014 10.1074/jbc.M113.532333
Moa Min et al., Phosphorylation of Xenopus p31comet potentiates mitotic checkpoint exit Cell Cycle April 2015 10.1080/15384101.2015.1033590
Kassardjian Ari et al., The Transcription Factor YY1 Is a Novel Substrate for Aurora B Kinase at G2/M Transition of the Cell Cycle PLoS One November 2012 10.1371/journal.pone.0050645
Cancer, Cell Cycle, Ser/Thr Kinases
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