Recombinant mouse EPHA1 (569-end) was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Catalog No. E13-11G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| E13-11G-05 | 5 ug | $226 | |
| E13-11G-10 | 10 ug | $325 | |
| E13-11G-BULK | BULK | Contact Us |
Overview:
EPHA1 is a member of the Eph family of receptor tyrosine kinases that have been implicated in mediating developmental events, particularly in the nervous system (1). Receptors in the Eph subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. EPHA1 seems to be a marker of the differentiated normal epidermis and its downregulation in nonmelanoma skin cancer may contribute to carcinogenesis of these very frequent human tumors. EPHA1 represents a new potential prognostic marker and therapeutic target in nonmelanoma skin cancer (2).
Gene Aliases:
EPH; EPHT; EPHT1; MGC163163
Genbank Number:
References:
1. Kullander, K. et al: Mechanisms and functions of Eph and ephrin signalling. Nat Rev Mol Cell Biol. 2002 Jul;3(7):475-86.
2. Hafner, C. et al: Expression profile of Eph receptors and ephrin ligands in human skin and downregulation of EphA1 in nonmelanoma skin cancer. Mod Pathol. 2006 Oct;19(10):1369-77
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
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Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~71 kDa
Ravanan P et al., IRE 1α is critical for Kaempferol‐induced neuroblastoma differentiation
The FEBS journal April 2019 10.1111/febs.14776
et al., Ripretinib (DCC-2618) Is a Switch Control Kinase Inhibitor of a Broad Spectrum of Oncogenic and Drug-Resistant KIT and PDGFRA Variants. Cancer cell February 2020
Angiogenesis, Cancer, Cardiovascular Disease, Neurobiology, Receptor Tyrosine Kinases
EPHB4, Active, E24-11G
EPHA2, Active, E14-11G
EPHA4, Active, E16-11G
Poly (4:1 Glu, Tyr) Peptide, P61-58
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