Overview:

PDGFRβ (platelet-derived growth factor receptor ) is a member of the PDGFR family of membrane receptors with intrinsic tyrosine kinase activity. PDGFRβ deficient mice are hemorrhagic, severely anemic and exhibit a defect in kidney glomeruli function (1). However, absence of PDGFRβ has no impact on major blood vessels and the heart. PDGFRβexpression and activity is elevated in several cancers and inhibition of PDGFRβ activity blocks progression of renal carcinoma in an animal model (2).

Gene Aliases:

JTK12; PDGFR; CD140B; PDGFR1

Genbank Number:

NM_002609

References:

1. Soriano, P: Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice. Genes Dev. 1994 Aug 15;8(16):1888-96.

2. Xu, L. et al: Blocking platelet-derived growth factor-D/platelet-derived growth factor receptor beta signaling inhibits human renal cell carcinoma progression in an orthotopic mouse model. Cancer Res. 2005 Jul 1;65(13):5711-9.