PKD2 is a novel phorbol ester- and growth factor-stimulated serine/threonine kinase that contains two cysteine-rich motifs at the N terminus, a pleckstrin homology domain, and a catalytic domain (1). It exhibits the strongest homology to the serine/threonine protein kinases PKD/PKCμ and PKCν. The PKD family of enzymes have been implicated in very diverse cellular functions, including Golgi organization and plasma membrane directed transport, metastasis, immune responses, apoptosis and cell proliferation (2).
HSPC187; DKFZp586E0820; PRKD2; PKC-D2
1. Sturany, S. et al: Molecular cloning and characterization of the human protein kinase D2. A novel member of the protein kinase D family of serine threonine kinases. J Biol Chem. 2001 Feb 2;276(5):3310-8.
2. Rykx, A. et al: Protein kinase D: a family affair. FEBS Lett. 2003 Jul 3;546(1):81-6.
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
F. Liachko Nicole et al., The Tau Tubulin Kinases TTBK1/2 Promote Accumulation of Pathological TDP-43 PLoS Genetics December 2014 10.1371/journal.pgen.1004803
R LaValle Courtney et al., Novel protein kinase D inhibitors cause potent arrest in prostate cancer cell growth and motility BMC Chemical Biology May 2010 10.1186/1472-6769-10-5
Apoptosis/Autophagy, Cardiovascular Disease, ERK/MAPK Pathway, Neurobiology, NfkB Pathway, PKA/PKC Pathway, Ser/Thr Kinases