Overview:

PKD2(G870E) is a glycine to glutamic acid mutation at 870 aa in PKD2 and appears as a somatic mutation in gastric adenocarcinoma samples. PKD2 is a novel phorbol ester- and growth factor-stimulated serine/threonine kinase that contains two cysteine-rich motifs at the N terminus, a pleckstrin homology domain, and a catalytic domain (1). It exhibits the strongest homology to the serine/threonine protein kinases PKD/PKCμ and PKCν. The PKD family of enzymes have been implicated in very diverse cellular functions, including Golgi organization and plasma membrane directed transport, metastasis, immune responses, apoptosis and cell proliferation (2).

Gene Aliases:

HSPC187; nPKC-D2; PRKD2

Genbank Number:

NM_016457

References:

1. Sturany, S. et al: Molecular cloning and characterization of the human protein kinase D2. A novel member of the protein kinase D family of serine threonine kinases. J Biol Chem. 2001 Feb 2;276(5):3310-8.

2. Rykx, A. et al: Protein kinase D: a family affair. FEBS Lett. 2003 Jul 3;546(1):81-6.