Home   >    Enzymes   >   Kinases

PFKFB2 Protein

Recombinant full-length human PFKFB2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. P322-30G


Shop Online



Catalog No. Pack Size Price (USD)
P322-30G-20 20 ug $215
P322-30G-50 50 ug $435
P322-30G-BULK BULK Contact Us  


Overview:

PFKFB2 is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. PFKFB2 has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. PFKFB2 regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle (1). PFKFB2 also functions as a homodimer. PFKFB2 play an important role in the regulation of muscle glycolysis during the first moments of exercise (2).


Gene Aliases:

PFK-2/FBPase-2


Genbank Number:


References:


1. Hilliker, C. E. et.al: Human and rat chromosomal localization of two genes for 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase by analysis of somatic cell hybrids and in situ hybridization. Genomics 10: 867-873, 1991.

2. Rovira J. et.al: Upregulation of heart PFK-2/FBPase-2 isozyme in skeletal muscle after persistent contraction. Pflugers Arch. 2012 Apr;463(4):603-13. doi: 10.1007/s00424-011-1068-5


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~84 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cell Cycle, Metabolic Disorder



SIGNALCHEM BIOTECH INC.


About

Terms of Service

Privacy Policy

Get the latest resources, updates and offers in your inbox