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PFKFB1, Active

Recombinant full-length human PFKFB1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. P321-10G


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Catalog No. Pack Size Price (USD)
P321-10G-05 5 ug $259
P321-10G-10 10 ug $380
P321-10G-BULK BULK Contact Us  


Overview:

PFKFB1 is a member of the family of bifunctional 6-phosphofructo-2-kinase: fructose-2, 6-biphosphatase enzymes which forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains (1). Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Regulation of fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis (2).


Gene Aliases:

F6PK; HL2K; PFRX


Genbank Number:


References:


1. Algaier, J.et.al: Molecular cloning, sequence analysis, and expression of a human liver cDNA coding for fructose-6,2-kinase:fructose-2,6-bisphosphatase. Biochem. Biophys. Res. Commun. 153: 328-333, 1988.

2. Darville, M. I. et.al: Complete nucleotide sequence coding for rat liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase derived from a cDNA clone. FEBS Lett. 224: 317-321, 1987.


Specific Activity:

Sample Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

80 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cell Cycle


RELATED PRODUCTS


  Fructose Kinase Assay Buffer I, F01-09

  Fructose Kinase Dilution Buffer I, F21-09

  D-Glucose-6-phosphate, F521-59

  D-Fructose-6-phosphate, F520-59


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