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PFKFB4, Active

Recombinant human PFKFB4 (2-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. P324-11G


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Catalog No. Pack Size Price (USD)
P324-11G-05 5 ug $259
P324-11G-10 10 ug $380
P324-11G-BULK BULK Contact Us  


Overview:

PFKFB4 (also known as 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-4) regulates the steady-state concentration of fructose-2, 6-bisphosphate, a potent activator of a key regulatory enzyme of glycolysis pathway called phosphofructokinase. Isozymes of PFKFB differ in the regions surrounding the catalytic core, which are important for the differential response to allosteric effectors and hormonal signals in different tissues (1). PFKFB4 is highly expressed in brain, heart, liver, muscle, placenta, adipose tissue, ovary, fallopian tubes, and testis (2).


Gene Aliases:

None


Genbank Number:


References:


1. Sakai, A. et.al: Cloning of cDNA encoding for a novel isozyme of fructose 6-phosphate,2-kinase/fructose 2,6-bisphosphatase from human placenta. J. Biochem. 119: 506-511, 1996.

2. Manzano, A.et.al: Cloning, expression and chromosomal localization of a human testis 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene. Gene 229: 83-89, 1999.


Specific Activity:

Sample Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

82 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cell Cycle


RELATED PRODUCTS


  Fructose Kinase Assay Buffer I, F01-09

  Fructose Kinase Dilution Buffer I, F21-09

  D-Glucose-6-phosphate, F521-59

  D-Fructose-6-phosphate, F520-59


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