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MKK4, Active

Recombinant human full-length MKK4 was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag.
Catalog No. M05-10H


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Catalog No. Pack Size Price (USD)
M05-10H-05 5 ug $226
M05-10H-10 10 ug $325
M05-10H-BULK BULK Contact Us  


Overview:

MKK4 is a member of the mitogen-activated protein kinase family and is involved in the stress-activated protein kinase pathway where it phosphorylates c-Jun NH2-terminal kinase (1). MKK4 is part of a signaling system that is stimulated in the presence of stress to the cell (including chemotherapy), and it controls differentiation and programmed cell death (apoptosis). MKK4 is central component of signal transduction pathways induced by mitogens and stresses. MKK4 genetic inactivation has been observed in a subset of pancreatic carcinomas, implicating deregulation of the stress-activated protein kinase pathway in pancreatic carcinogenesis (2).


Gene Aliases:

MAP2K4, JNKK, MEK4, SEK1, JNKK1, SERK1, MAPKK4, PRKMK4


Genbank Number:


References:


1. Karl Deacon, K. et al: Characterization of the Mitogen-activated Protein Kinase Kinase 4 (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/p38 Pathways Regulated by MEK Kinases 2 and 3. J. Biol. Chem.1997; 272 ( 22): 14489-14496.

2. Wei, X. et al: MAP2K4/MKK4 Expression in Pancreatic Cancer. Clinical Cancer Res. 2004; 10, 8516-8520.


Specific Activity:

Sample Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~46 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Ser/Thr Kinases


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