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MST1, Active

Recombinant full-length human MST1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. S25-10G


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Catalog No. Pack Size Price (USD)
S25-10G-05 5 ug $226
S25-10G-10 10 ug $325
S25-10G-BULK BULK Contact Us  


Overview:

MST1 belongs to a family of proteins that share similarity with a budding yeast serine/threonine kinase, sterile-20 (Ste20). Endogenous full-length MST1 is activated by a variety of stressful stimuli, accompanied by the secondary appearance of a 36 kDa Thr183-phosphorylated, caspase-cleaved catalytic fragment (1). Recombinant MST1 undergo a robust autoactivation in vitro, mediated by an intramolecular autophosphorylation on the activation loop of an MST dimmer. MST1 can initiate apoptosis when transiently overexpressed in mammalian cells. Interference with the ability of endogenous MST1 to associate with the putative tumor suppressor proteins Nore1/RASSF can inhibit Ras-induced apoptosis (2).


Gene Aliases:

KRS2; YSK3; DKFZp686A2068; STK4


Genbank Number:


References:


1. De Souza, P M. et al: Mammalian Sterile20-like kinase 1 and the regulation of apoptosis. Biochem Soc Trans. 2004 Jun;32(Pt3):485-8.

2. Avruch, J. et al: Nore1 and RASSF1 Regulation of Cell Proliferation and of the MST1/2 Kinases. Methods Enzymol. 2005;407:290-310.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~83kDa



Product Datasheets



RESEARCH AREAS

AKT/PKB Pathway, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, JNK/SAPK Pathway, Neurobiology, Receptor Tyrosine Kinases


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