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TRIO, Active

Recombinant human TRIO (2627-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. T16-11G


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Catalog No. Pack Size Price (USD)
T16-11G-05 5 ug $226
T16-11G-10 10 ug $325
T16-11G-BULK BULK Contact Us  


Overview:

TRIO (Triple functional domain protein) belongs to CAMK Ser/Thr protein kinase family with 5 isoforms produced by alternative splicing. It encodes two Dbl-homology-Pleckstrin-homology (DH-PH) Rho-GEF units with different specificities and a C-terminal serine/threonine kinase domain. It is a Rho-guanine nucleotide exchange factors (GEFs) that catalyzes exchange of GDP for GTP on small Rho-GTPases, such as Rac1, RhoG and RhoA. TRIO was originally identified as a binding partner of the transmembrane tyrosine phosphatase LAR, and they together play a role in coordinating cell-matrix and cytoskeletal rearrangements required for cell migration and cell growth.


Gene Aliases:

(None)


Genbank Number:


References:


1. Debant A, et al. The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains. Proc Natl Acad Sci U S A. 93:5466-71. 1996.

2. van Rijssel J, et al: The many faces of the guanine-nucleotide exchange factor trio. Cell Adh Migr. 6:482-7. 2012.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~82 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, ERK/MAPK Pathway, Neurobiology, Ser/Thr Kinases


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